Last update
5/1/2025
Research Authors

Overview

SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Moderately Good
Based on 22 Reviews
7.8
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Sodium (from Sodium Hyaluronate)
10 mg
< 1 %
Hyaluronic Acid (from Sodium Hyaluronate)
100 mg
L-Proline (Free-Form)
100 mg
Alpha Lipoic Acid
50 mg
Grape Seed Extract (Vitis vinifera)(Standardized for Polyphenols)
25 mg

Top Medical Research Studies

8
Polynucleotide sodium reduces knee pain
We engaged in a pilot study comparing the effectiveness of polynucleotide sodium with sodium hyaluronate for knee osteoarthritis pain relief. With 15 patients divided into three groups, all received ultrasound-guided injections over three weeks.

Our findings showed that those treated with polynucleotide sodium experienced a significant reduction in weight-bearing pain compared to the hyaluronic acid group after six weeks. However, the other measures of pain and quality of life did not exhibit notable differences between the groups.

Overall, polynucleotide sodium proved more effective in alleviating weight-bearing pain in this limited study.
Read More

Most Useful Reviews

9
Knee pain relief
4 people found this helpful
I can't go without it now! Especially in the cold, I no longer experience knee pain. This product has become essential not only for my joints but also for my hair and skin.
Read More
9
Mobility restored
1 people found this helpful
Life-Changing Duo: Hyaluronic Acid and Collagen Supplements! I've had dry skin and joint discomfort for years, but after two weeks of taking these supplements, everything changed! My bone pain has disappeared, allowing me to walk comfortably again. Now, I can enjoy long walks without discomfort. This regimen is straightforward: I take Hyaluronic Acid with meals for hydration and Collagen before bedtime for joint comfort. I'm thrilled with the results and will definitely continue purchasing.
Read More
9
Relief for knees
1 people found this helpful
Bought for my husband who, after 15 days, feels the benefits on his osteoarthritis pain in his knees. He is much more relieved and in less pain than before taking this supplement. I'm going to buy some for my mum to help relieve her where the osteoarthritis is more advanced.
Read More

Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
  • All Researches
8
Polynucleotide sodium reduces knee pain
We engaged in a pilot study comparing the effectiveness of polynucleotide sodium with sodium hyaluronate for knee osteoarthritis pain relief. With 15 patients divided into three groups, all received ultrasound-guided injections over three weeks.

Our findings showed that those treated with polynucleotide sodium experienced a significant reduction in weight-bearing pain compared to the hyaluronic acid group after six weeks. However, the other measures of pain and quality of life did not exhibit notable differences between the groups.

Overall, polynucleotide sodium proved more effective in alleviating weight-bearing pain in this limited study.
Read More

User Reviews

USERS' SCORE
Moderately Good
Based on 22 Reviews
7.8
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Knee pain relief
4 people found this helpful
I can't go without it now! Especially in the cold, I no longer experience knee pain. This product has become essential not only for my joints but also for my hair and skin.
Read More
9
Mobility restored
1 people found this helpful
Life-Changing Duo: Hyaluronic Acid and Collagen Supplements! I've had dry skin and joint discomfort for years, but after two weeks of taking these supplements, everything changed! My bone pain has disappeared, allowing me to walk comfortably again. Now, I can enjoy long walks without discomfort. This regimen is straightforward: I take Hyaluronic Acid with meals for hydration and Collagen before bedtime for joint comfort. I'm thrilled with the results and will definitely continue purchasing.
Read More
9
Relief for knees
1 people found this helpful
Bought for my husband who, after 15 days, feels the benefits on his osteoarthritis pain in his knees. He is much more relieved and in less pain than before taking this supplement. I'm going to buy some for my mum to help relieve her where the osteoarthritis is more advanced.
Read More
9
Significant reduction
1 people found this helpful
I have been using this product for a month now alongside collagen, and it reduced my bone pain by 60-70%. I stopped the painkillers after about a week of using it, and I am very pleased with the outcome.
Read More
9
Joint pain eradicated
1 people found this helpful
Excellent! This 100mg dose has resolved my joint pain completely.
Read More

Frequently Asked Questions

9
Mobility restored
1 people found this helpful
Life-Changing Duo: Hyaluronic Acid and Collagen Supplements! I've had dry skin and joint discomfort for years, but after two weeks of taking these supplements, everything changed! My bone pain has disappeared, allowing me to walk comfortably again. Now, I can enjoy long walks without discomfort. This regimen is straightforward: I take Hyaluronic Acid with meals for hydration and Collagen before bedtime for joint comfort. I'm thrilled with the results and will definitely continue purchasing.
9
Relief for knees
1 people found this helpful
Bought for my husband who, after 15 days, feels the benefits on his osteoarthritis pain in his knees. He is much more relieved and in less pain than before taking this supplement. I'm going to buy some for my mum to help relieve her where the osteoarthritis is more advanced.
9
Relief from bone pain
1 people found this helpful
I bought a gilauron for my husband for his bones, as he had an issue with the meniscus. He felt relief after just a week.
9
Significant reduction
1 people found this helpful
I have been using this product for a month now alongside collagen, and it reduced my bone pain by 60-70%. I stopped the painkillers after about a week of using it, and I am very pleased with the outcome.
9
Knee pain relief
4 people found this helpful
I can't go without it now! Especially in the cold, I no longer experience knee pain. This product has become essential not only for my joints but also for my hair and skin.
7.5
Improved joint health
Excellent for skin and joints! I have noticed much improvement in my skin, especially around my eyes, and my joints are much less sore. Hyaluronic acid is great for skin health, joint lubrication, and relieving bone pain. All this in a small, easy-to-swallow capsule. I am definitely sold on this product!
0
No improvement noted
It has no effect. Despite taking it alongside other supplements, my bone pain has not improved.
7.5
Improved joint pain
This hyaluronic acid product is of good quality and reasonably priced. At 67 years old, I've noticed a considerable improvement in my joint pain since taking it.
9
Joint pain eradicated
1 people found this helpful
Excellent! This 100mg dose has resolved my joint pain completely.
10
Discomfort vanished
After injuring my knee during a fitness class, I took two pills daily for two weeks, and all discomfort has completely disappeared. I plan to continue taking them.
9
Knee pain relief
I liked the result after taking collagen types 1 and 3 along with hyaluronic acid. I took 2 capsules for two months to relieve aching pain in my knees. After about a month, I felt relief, and then the bone pain stopped entirely. Now, after a year, I plan to repeat the course for 2 to 3 months.
8
Polynucleotide sodium reduces knee pain
We engaged in a pilot study comparing the effectiveness of polynucleotide sodium with sodium hyaluronate for knee osteoarthritis pain relief. With 15 patients divided into three groups, all received ultrasound-guided injections over three weeks.

Our findings showed that those treated with polynucleotide sodium experienced a significant reduction in weight-bearing pain compared to the hyaluronic acid group after six weeks. However, the other measures of pain and quality of life did not exhibit notable differences between the groups.

Overall, polynucleotide sodium proved more effective in alleviating weight-bearing pain in this limited study.

References

  1. Kim JY, Kim YN, Lee YJ, Sim SE, Ko YR, et al. Pilot Study to Evaluate the Efficacy of Polynucleotide Sodium Compared to Sodium Hyaluronate and Crosslinked Sodium Hyaluronate in Patients with Knee Osteoarthritis. J Clin Med. 2021;10. 10.3390/jcm10051138
image